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Examine finds elevated danger of dementia — ScienceDaily

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Head harm in america is frequent, with over 23 million adults age 40 or older reporting a historical past of head harm with lack of consciousness. Many head accidents could be brought on by a number of various conditions — from automobile and motorbike accidents to sports activities accidents. What’s extra, it has change into more and more acknowledged that the consequences from head accidents are long-lasting. New analysis led by the Perelman Faculty of Medication on the College of Pennsylvania reveals {that a} single head harm may result in dementia later in life. This danger additional will increase because the variety of head accidents sustained by a person will increase. The findings additionally counsel stronger associations of head harm with danger of dementia amongst girls in comparison with amongst males and amongst white as in comparison with amongst Black populations.

The researchers, whose findings have been revealed right now in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Affiliation, carried out the investigation utilizing information from the Atherosclerosis Danger in Communities (ARIC) Examine, which aimed to uncover associations between head harm and dementia over the span of 25 years in a various inhabitants in america. Beforehand, information on traumatic mind harm has been restricted to pick out populations, resembling navy and medical claims databases. These are among the many first findings to particularly examine head harm and dementia danger in each Black and white populations, in addition to amongst each men and women, in a community-based setting.

“Head harm is a major danger issue for dementia, but it surely’s one that may be prevented. Our findings present that the variety of head accidents matter — extra head accidents are related to higher danger for dementia,” stated lead investigator, Andrea L.C. Schneider, MD, PhD, an assistant professor of Neurology at Penn. “The dose-dependence of this affiliation means that prevention of head harm may mitigate some danger of dementia later in life. Whereas head harm just isn’t the one danger issue for dementia, it’s one danger issue for dementia that’s modifiable by habits adjustments resembling sporting helmets and seat belts.”

The findings present that in comparison with individuals who by no means skilled a head harm, a historical past of a single prior head harm was related to a 1.25 instances elevated danger of dementia, and a historical past of two or extra prior head accidents was related to over 2 instances elevated danger of dementia in comparison with people and not using a historical past of head harm. General, 9.5 % of all dementia circumstances within the examine inhabitants may very well be attributed to at the very least one prior head harm.

For instance the connection between dementia and head accidents, the authors gathered information from a various cohort with a imply baseline age of 54 years, comprised of 56 % feminine and 27 % Black individuals from 4 completely different communities throughout america. Contributors have been adopted for a median of 25 years via as much as six in-person visits and semi-annual phone follow-ups. Information on head accidents of individuals was drawn from hospital data, in addition to self-reporting from some individuals.


Earlier analysis on dementia and traumatic mind accidents suggests that ladies are at increased danger for dementia in comparison with males. Moreover, Black populations general are at increased danger for dementia in comparison with people who find themselves white. Nevertheless, few prior research have evaluated for attainable variations in associations of head harm with dementia danger by intercourse and race.

This information from the ARIC examine discovered proof that females have been extra more likely to expertise dementia on account of head harm than males. Additional, the examine confirmed that though there may be elevated dementia danger related to head harm amongst each White and Black individuals, White individuals have been at increased danger for dementia after head harm in comparison with Black individuals. The authors conclude that extra analysis is required to higher perceive causes for these noticed intercourse and race variations within the affiliation of head harm with dementia danger.

“Given the robust affiliation of head harm with dementia, there is a crucial want for future analysis targeted on prevention and intervention methods aimed toward lowering dementia after head harm,” Schneider stated. “The outcomes of this examine have already led to a number of ongoing analysis tasks, together with efforts to uncover the causes of head injury-related dementia in addition to investigations into causes underlying the noticed intercourse and race variations within the danger of dementia related to head harm.”

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Materials offered by University of Pennsylvania School of Medicine. Be aware: Content material could also be edited for fashion and size.

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