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BMI1, a promising gene to guard in opposition to Alzheimer’s illness

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One other step in the direction of understanding Alzheimer’s illness has been taken on the Maisonneuve-Rosemont Hospital Analysis Centre.

Molecular biologist Gilbert Bernier, and professor of neurosciences at Université de Montréal, has found a brand new operate for the BMI1 gene, which is thought to inhibit mind getting old. The outcomes of his work have simply been revealed in Nature Communications.

In his laboratory, Bernier was capable of set up that BMI1 was required to forestall the DNA of neurons from disorganizing in a specific manner known as G4 buildings. This phenomenon happens within the brains of individuals with Alzheimer’s illness, however not in wholesome aged individuals. Thus, BMI1 would shield in opposition to Alzheimer’s by stopping, amongst different issues, the extreme formation of G4s that disrupt the functioning of neurons.

“This discovery provides to our data of the basic mechanisms resulting in Alzheimer’s,” mentioned Bernier. “There may be nonetheless no treatment for this illness, which now impacts practically a million Canadians. Any advance within the discipline brings hope to all these individuals and their households.”

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In earlier articles revealed within the journals Cell Stories and Scientific Stories, Bernier demonstrated that the expression of the BMI1 gene is particularly diminished within the brains of individuals with Alzheimer’s illness. He additionally confirmed that inactivation of BMI1 in cultured human neurons or in mice was adequate to recapitulate all of the pathological markers related to Alzheimer’s illness.

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